Ditary fats carbohydrates vascular diseade new england journal august 1967
A classic paper!
The paper you're referring to is likely "Dietary Fats, Carbohydrates, and Vascular Disease" by Ancel Keys, et al., published in the New England Journal of Medicine (NEJM) in August 1967.
This paper is a landmark study that investigated the relationship between dietary fat, carbohydrate, and the risk of coronary heart disease (CHD). The study was conducted by the Seven Countries Study, a collaborative effort between researchers from seven countries: the United States, Japan, Italy, Greece, the Netherlands, Finland, and Yugoslavia.
The study analyzed data from over 12,000 men aged 40-59 years, who were followed for 5-10 years. The researchers found that:
- The highest rates of CHD were found in the United States, Finland, and the Netherlands, which had high intakes of saturated fats and cholesterol.
- The lowest rates of CHD were found in Japan, Greece, and Italy, which had lower intakes of saturated fats and cholesterol.
- The risk of CHD was significantly higher in men who consumed high amounts of saturated fats and cholesterol, compared to those who consumed lower amounts.
- The risk of CHD was also higher in men who consumed high amounts of carbohydrates, particularly refined carbohydrates.
The study's findings supported the idea that a diet high in saturated fats and cholesterol increases the risk of CHD, and that a diet low in saturated fats and cholesterol, and high in unsaturated fats and fiber, may help to reduce this risk.
This study has had a significant impact on our understanding of the relationship between diet and cardiovascular disease, and has influenced public health recommendations and dietary guidelines for many years.