Setien would love 43 more clasicos for messi ahead of record setting outing for barcelona star

I think there may be a slight mistake in your statement. Setién is a former coach of Barcelona, not a player, so he wouldn't "love" anything related to Messi's goals. Additionally, Messi has already played in many El Clásicos, not just 43 more.

However, I assume you meant to say that Setién would love to see Messi play in many more El Clásicos, which is a possibility given Messi's incredible career and his continued dominance on the pitch.

As for the record-setting outing, Messi has already broken numerous records throughout his career, and it's likely that he will continue to do so as long as he remains active.