New antimalarial drugs

There are several new antimalarial drugs that have been developed or are in the pipeline to combat malaria, a disease that still affects millions of people worldwide. Here are some examples:

  1. Tafenoquine: Tafenoquine is a new antimalarial drug that has been approved by the US FDA and the European Medicines Agency (EMA). It is a single-dose treatment for malaria caused by Plasmodium vivax and Plasmodium falciparum.
  2. KAF156: KAF156 is a new antimalarial drug that has shown promising results in clinical trials. It is a dihydroorotate dehydrogenase (DHODH) inhibitor, which works by blocking the parasite's ability to synthesize pyrimidine nucleotides.
  3. GSK333: GSK333 is a new antimalarial drug that has been developed by GlaxoSmithKline. It is a fumarate-based compound that has shown activity against both Plasmodium falciparum and Plasmodium vivax.
  4. OZ439: OZ439 is a new antimalarial drug that has been developed by Novartis. It is a dihydroartemisinin-piperaquine combination that has shown activity against both Plasmodium falciparum and Plasmodium vivax.
  5. Fosmidomycin: Fosmidomycin is a new antimalarial drug that has been developed by the US National Institutes of Health (NIH). It is a antibiotic that works by inhibiting the parasite's ability to synthesize isoprenoids.
  6. Artemisone: Artemisone is a new antimalarial drug that has been developed by the US NIH. It is a semi-synthetic derivative of artemisinin, a natural product that has been used to treat malaria for centuries.
  7. Radepagin: Radepagin is a new antimalarial drug that has been developed by the Chinese company, Jiangsu Province Pharmaceutical Co., Ltd. It is a dihydroartemisinin-piperaquine combination that has shown activity against both Plasmodium falciparum and Plasmodium vivax.
  8. Eurartesim: Eurartesim is a new antimalarial drug that has been developed by the European company, Sanofi. It is a dihydroartemisinin-piperaquine combination that has shown activity against both Plasmodium falciparum and Plasmodium vivax.
  9. Dihydroartemisinin-piperaquine: Dihydroartemisinin-piperaquine is a new antimalarial drug that has been developed by the Chinese company, Guilin Pharmaceutical Co., Ltd. It is a combination of dihydroartemisinin and piperaquine that has shown activity against both Plasmodium falciparum and Plasmodium vivax.
  10. Pyronaridine-artesunate: Pyronaridine-artesunate is a new antimalarial drug that has been developed by the Chinese company, Guilin Pharmaceutical Co., Ltd. It is a combination of pyronaridine and artesunate that has shown activity against both Plasmodium falciparum and Plasmodium vivax.

These are just a few examples of the new antimalarial drugs that are being developed to combat malaria. It's worth noting that the development of new antimalarial drugs is an ongoing process, and new compounds are being discovered and tested all the time.