Antipsychotic drugs old generation new generation

Here's a comparison of old generation antipsychotic drugs (typical antipsychotics) and new generation antipsychotic drugs (atypical antipsychotics):

Old Generation (Typical) Antipsychotics:

1. Chlorpromazine (Thorazine) - introduced in 1955
2. Haloperidol (Haldol) - introduced in 1958
3. Fluphenazine (Prolixin) - introduced in 1959
4. Thioridazine (Mellaril) - introduced in 1959
5. Perphenazine (Trilafon) - introduced in 1961
6. Trifluoperazine (Stelazine) - introduced in 1962
7. Thiothixene (Navane) - introduced in 1964
8. Loxapine (Loxitane) - introduced in 1967
9. Molindone (Moban) - introduced in 1972

Characteristics:

• High potency and efficacy in treating positive symptoms of schizophrenia (e.g., hallucinations, delusions)
• High risk of extrapyramidal symptoms (EPS), such as Parkinsonism, dystonia, and akathisia
• High risk of tardive dyskinesia (TD), a neurological disorder characterized by involuntary movements
• May cause sedation, weight gain, and metabolic changes
• Often used in combination with other medications to manage symptoms

New Generation (Atypical) Antipsychotics:

1. Risperidone (Risperdal) - introduced in 1994
2. Olanzapine (Zyprexa) - introduced in 1996
3. Quetiapine (Seroquel) - introduced in 1997
4. Ziprasidone (Geodon) - introduced in 2001
5. Aripiprazole (Abilify) - introduced in 2002
6. Paliperidone (Invega) - introduced in 2006
7. Asenapine (Saphris) - introduced in 2009
8. Lurasidone (Latuda) - introduced in 2010
9. Cariprazine (Vraylar) - introduced in 2015

Characteristics:

• Lower risk of EPS and TD compared to typical antipsychotics
• Lower risk of sedation and metabolic changes
• May have a more favorable side effect profile, including improved cognitive function and mood stability
• Often used as monotherapy to manage symptoms
• May be used to treat a broader range of conditions, including bipolar disorder, depression, and anxiety disorders

Key differences:

• Atypical antipsychotics have a more favorable side effect profile, with a lower risk of EPS and TD.
• Atypical antipsychotics are often used as monotherapy, whereas typical antipsychotics are often used in combination with other medications.
• Atypical antipsychotics may be used to treat a broader range of conditions, including conditions beyond schizophrenia.

It's important to note that both old and new generation antipsychotics have their own set of benefits and risks, and the choice of medication depends on individual patient needs and circumstances.