Patient JA portrayed by Marcus Ellison Jr.
haha preworkout go glug glug
😳 What if it was all just part of the simulation? 😳

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This particular kind of pre workout supplement should not be dry scooped. It is a dry powder that is formulated to be mixed with water. Powder dry like this is not designed to absorb through buccal mucosa. If it was designed to be, then it would in fact, let the pre hit harder since it wouldn’t go to the liver first to be broken down, that is, bypass first-pass metabolism. If that happened, the amounts of some key ingredients would likely be lower. Instead, by doing this, you’re creating a choking hazard for yourself because of a troll and haha funny laughs at the expense of your own health. You likely can damage your lungs if you cough and breathe in enough powder because you tried this.

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These cases are patients who I, or my colleagues have seen. They are de-identified and many instances have been presented in more depth in an academic setting. These videos are not individual medical advice and are for general educational purposes only. I do not give medical advice over the internet, see your physician in person for that.

References:

Broadley KJ. The vascular effects of trace amines and alphamethylphenylethylamines. Pharmacol Ther. 2010;125:363–375.

Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications.

Hemorrhagic Stroke in a Young Healthy Male Following Use of Pre-Workout Supplement.

Hypertonic Saline for ICP Reduction in Traumatic Brain Injury Patients: An Evolving Practice.

K Adulterated with Phenylethylamine and Associated Intracerebral Hemorrhage: Linking Toxicologists and Public Health Officials to Identify Adulterants

Liang CS, Sprecher D. Cardiovascular actions of beta-phenylethylamine. Am J Phys. 1979;236(4):H592–H595.

Wijers CHW, Visser MC, van Litsenburg RTH, Niesink RJM, Willemse RB, Croes EA. Haemorrhagic stroke related to the use of 4-fluoroalphamethylphenylethylamine. J Neurol. 2018;265:1607–1611.

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Cohen PA, Zeijlon R, Nardin R, Keizers PH, Venhuis B. Hemorrhagic stroke probably caused by exercise combined with a sports supplement containing β-methylphenyl-ethylamine (BMPEA): a case report. Ann Intern Med. 2015;162:879–880.

Youdim, M. B. H., & Finberg, J. P. M. (1991). New directions in monoamine oxidase A and
B selective inhibitors and substrates. Biochem Pharmacol 41, 155–162.

β-phenylethylamine, a small molecule with a large impact

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